Injectable hydrogel platform with biodegradable Dawson-type polyoxometalate and R848 for combinational photothermal-immunotherapy of cancer
Yandi Liu, Yuyang Han, Sha Lu, Yingjiao Wu, Juan Li, Xiaoyi Sun, Jun Yan
Abstract
and good photostability during five cycles. By further incorporation of R848, the obtained R848/POM@GG exerts synergetic photothermal-immunotherapy on solid tumors, giving a high tumor inhibition rate of 99.3% and negligible lung metastases in the breast cancer mice models. A strong antitumor immune system with significantly elevated TNF-α, IL-2, and IL-6 levels is activated by R848. Additionally, the POM clusters gradually degrade to nontoxic molybdate in the physiological environment. Overall, the injectable hydrogel platform of R848/POM@GG has great translational potential for localized antitumor treatments.
Topics & Concepts
Photothermal therapyPolyoxometalateImmunotherapyChemistryCancer researchPhotothermal effectCancerMaterials scienceNanotechnologyMedicineInternal medicineBiochemistryCatalysisNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced Photocatalysis Techniques