Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression
Xi Chen, Tianlan Lan, Yue Wang, Yong He, Zhonghao Wu, Yu Tian, Yan Li, Mengge Bai, Wei Zhou, Hanping Zhang, Ke Cheng, Peng Xie
Abstract
were increased. Upregulation of SERT and EAAT2 in protein expression level were also validated, while no significant changes were found in TH, AADC, MAOA, VMAT2, GAD1, GLUL and SNAT1. Our findings firstly provide evidence about the alteration of metabolites and related molecules in the EC of mice model of depression, implying the potential mechanism in MDD pathology.
Topics & Concepts
Downregulation and upregulationEntorhinal cortexEndocrinologyWestern blotInternal medicineMajor depressive disorderHippocampusChemistryMedicineBiochemistryAmygdalaGeneTryptophan and brain disordersStress Responses and CortisolNeuroscience and Neuropharmacology Research