Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis
Vincent Martin, Sandip V. Jadhav, Peter H. G. Egelund, Raphael Liffert, Henrik Johansson, Tobias Krüger, Kim F. Haselmann, Sebastian T. Le Quement, Fernando Alberício, Frank Dettner, Carolin C. Lechner, Ralph Schönleber, Daniel Sejer Pedersen
Abstract
Binary solvent mixtures with a suitable polarity and viscosity profile are viable green alternatives to DMF in solid-phase peptide synthesis.
Topics & Concepts
Polarity (international relations)SolventViscosityPhase (matter)ChemistryBinary numberPeptideSolvent polarityChromatographyPeptide synthesisChemical engineeringOrganic chemistryMaterials scienceBiochemistryComposite materialArithmeticEngineeringMathematicsCellChemistry and Chemical EngineeringChemical Synthesis and AnalysisComputational Drug Discovery Methods