Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum
N. Sumru Bayın, Doğukan Mizrak, Daniel N. Stephen, Zhimin Lao, Peter A. Sims, Alexandra L. Joyner
Abstract
is required for adaptive reprogramming by orchestrating a glial-to-neural switch in vivo following injury. Thus, we provide molecular and cellular insights into context-dependent progenitor plasticity and repair mechanisms in the brain.
Topics & Concepts
CerebellumProgenitor cellProgenitorNeuroscienceBiologyStem cellCell biologyEvolutionary biologyMitochondrial Function and PathologyNeurogenesis and neuroplasticity mechanismsRNA regulation and disease