Neuromedin B receptor stimulation of Cav3.2 T-type Ca<sup>2+</sup> channels in primary sensory neurons mediates peripheral pain hypersensitivity
Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao
Abstract
-dependent AMPK/PKA pathway. In mouse models, this mechanism appears to drive the hyperexcitability of TG neurons and induce pain hypersensitivity.
Topics & Concepts
Gene knockdownAMPKProtein kinase AChemistryStimulationSmall hairpin RNADorsal root ganglionEndocrinologyPharmacologyInternal medicineKinaseMedicineBiologyNeuroscienceSensory systemBiochemistryApoptosisPain Mechanisms and TreatmentsIon channel regulation and functionNeuropeptides and Animal Physiology