TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating “one-step” NLRP3 inflammasome in human monocytes
Mengdan Chen, Yu Shi, Yuhui Gao, Jiaxun Li, Xun Wang, Bin Wei, Guangxun Meng
Topics & Concepts
InflammasomeAIM2TLR2Cell biologyTRIFSignal transductionLipopolysaccharideInnate immune systemChemistryNOD2InflammationTLR4BiologyImmune systemImmunologyToll-like receptorInflammasome and immune disordersImmune Response and InflammationHeme Oxygenase-1 and Carbon Monoxide