End-Tidal to Arterial P <scp>co</scp> 2 Ratio as Guide to Weaning from Venovenous Extracorporeal Membrane Oxygenation
Stefano Lazzari, Federica Romitti, Mattia Busana, Francesco Vassalli, Matteo Bonifazi, Matteo Maria Macrí, Lorenzo Giosa, Francesca Collino, Daniel Heise, Martin Golinski, Simone Gattarello, Lars-Olav Harnisch, Serena Brusatori, Roberta Maj, Carmelo Zinnato, Konrad Meissner, Michael Quintel, Onnen Moerer, John J. Marini, Barnaby Sanderson, Luigi Camporota, Luciano Gattinoni
Abstract
Abstract Rationale Weaning from venovenous extracorporeal membrane oxygenation (VV-ECMO) is based on oxygenation and not on carbon dioxide elimination. Objectives To predict readiness to wean from VV-ECMO. Methods In this multicenter study of mechanically ventilated adults with severe acute respiratory distress syndrome receiving VV-ECMO, we investigated a variable based on CO2 elimination. The study included a prospective interventional study of a physiological cohort (n = 26) and a retrospective clinical cohort (n = 638). Measurements and Main Results Weaning failure in the clinical and physiological cohorts were 37% and 42%, respectively. The main cause of failure in the physiological cohort was high inspiratory effort or respiratory rate. All patients exhaled similar amounts of CO2, but in patients who failed the weaning trial, V˙ e was higher to maintain the PaCO2 unchanged. The effort to eliminate one unit-volume of CO2, was double in patients who failed (68.9 [42.4–123] vs. 39 [20.1–57] cm H2O/[L/min]; P = 0.007), owing to the higher physiological Vd (68 [58.73] % vs. 54 [41.64] %; P = 0.012). End-tidal partial carbon dioxide pressure (Pet CO2)/PaCO2 ratio was a clinical variable strongly associated with weaning outcome at baseline, with area under the receiver operating characteristic curve of 0.87 (95% confidence interval [CI], 0.71–1). Similarly, the Pet CO2/PaCO2 ratio was associated with weaning outcome in the clinical cohort both before the weaning trial (odds ratio, 4.14; 95% CI, 1.32–12.2; P = 0.015) and at a sweep gas flow of zero (odds ratio, 13.1; 95% CI, 4–44.4; P &lt; 0.001). Conclusions The primary reason for weaning failure from VV-ECMO is high effort to eliminate CO2. A higher Pet CO2/PaCO2 ratio was associated with greater likelihood of weaning from VV-ECMO.