Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors
Xiaodong Dou, Huixia Huang, Lan Jiang, Guiwang Zhu, Hongwei Jin, Ning Jiao, Liangren Zhang, Zhenming Liu, Lihe Zhang
Topics & Concepts
ChemistryLead compoundT790MStructure–activity relationshipStereochemistryKinaseCombinatorial chemistryDrug discoverySelectivityPharmacologyBiochemistryIn vitroReceptorEpidermal growth factor receptorGefitinibCatalysisMedicineMelanoma and MAPK PathwaysCancer Mechanisms and TherapySynthesis and biological activity