Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral <scp>NCP</scp> Pincer Iridium Complexes
Qian Lu, Xixia Tang, Yulei Wang, Guixia Liu, Zheng Huang
Abstract
Comprehensive Summary The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho ‐substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of ( S )‐neobenodine.
Topics & Concepts
ChemistryIridiumTransfer hydrogenationCatalysisPincer movementCombinatorial chemistryEthanolAsymmetric hydrogenationSolventOrganic chemistryEnantioselective synthesisRutheniumAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisCatalysis for Biomass Conversion