Palladium-Catalyzed Regiospecific <i>peri-</i> and <i>ortho-</i>C–H Oxygenations of Polyaromatic Rings Mediated by Tunable Directing Groups
Jing Jiang, Dandan Yuan, Congzhe Ma, Wanbin Song, Yaoyu Lin, Lihong Hu, Yinan Zhang
Abstract
oxygenation to readily access a wide array of polyaromatic phenols without pre- and postmanipulation of directing groups. The systematic mechanistic investigation, including deuterium-labeling experiments, palladacycle trapping, and DFT calculations, reveals that the tunable ligand-assisted C-H bond cleavage played a crucial role during the reaction process.
Topics & Concepts
ChemistryPalladiumCatalysisCleavage (geology)Ligand (biochemistry)Combinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryReceptorFracture (geology)BiochemistryGeotechnical engineeringEngineeringCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis