Stabilization and Binding of [V<sub>4</sub>O<sub>12</sub>]<sup>4−</sup> and Unprecedented [V<sub>20</sub>O<sub>54</sub>(NO<sub>3</sub>)]<sup>n−</sup> to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V<sup>IV</sup>O(acetylacetonato)<sub>2</sub>
Giarita Ferraro, Gabriella Tito, Giuseppe Sciortino, Eugenio Garribba, Antonello Merlino
Abstract
Abstract High‐resolution crystal structures of lysozyme in the presence of the potential drug V IV O(acetylacetonato) 2 under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V IV to V V and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V 4 O 12 ] 4− , which interacts with lysozyme non‐covalently, and the unprecedented [V 20 O 54 (NO 3 )] n− , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.
Topics & Concepts
LysozymeCrystallographyCovalent bondMoleculeChemistryAdductCrystal structureResidue (chemistry)X-ray crystallographyHigh resolutionStereochemistryPhysicsDiffractionBiochemistryRemote sensingGeologyOrganic chemistryOpticsPolyoxometalates: Synthesis and ApplicationsVanadium and Halogenation ChemistryMetal-Organic Frameworks: Synthesis and Applications