Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction
Rachel C. Kelley, Lauren Gabriel Betancourt, Andrea M. Noriega, Suzanne C. Brinson, Nuria Curbelo-Bermudez, Dongwoo Hahn, Ravi A. Kumar, Eliza Balazic, Derek R. Muscato, Terence E. Ryan, Robbert van der Pijl, Shengyi Shen, Coen A. C. Ottenheijm, Leonardo F. Ferreira
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a condition with phenotype-specific features highly prevalent in postmenopausal women and skeletal myopathy contributing to disease development and progression. We advanced a rat model of postmenopausal HFpEF with key cardiovascular and systemic features of the disease. Our study shows that the skeletal myopathy of postmenopausal HFpEF includes loss of limb muscle-specific force independent of atrophy, mitochondrial dysfunction, and oxidized shift in redox balance.