Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP
Jacqueline A. Carozza, Jenifer A. Brown, Volker Böhnert, Daniel Fernández, Yasmeen AlSaif, Rachel E. Mardjuki, Mark Smith, Lingyin Li
Topics & Concepts
PhosphodiesteraseExtracellularSmall moleculeChemistryMetalloproteinaseEnzymeCell biologyBiochemistryBiologyPhosphodiesterase function and regulationSynthesis and Catalytic ReactionsNeutrophil, Myeloperoxidase and Oxidative Mechanisms