Multiepitope glycan based laser assisted fluorescent nanocomposite with dual functionality for sensing and ablation of<i>Pseudomonas aeruginosa</i>
Priyanka Garg, Nitesh Priyadarshi, Mayur D. Ambule, Gurmeet Kaur, Sunaina Kaul, Ritika Gupta, Poonam Sagar, Geetika Bajaj, Binduma Yadav, Vikas Rishi, Bhupesh Goyal, Ajay Srivastava, Nitin Kumar Singhal
Abstract
The study utilizes multivalency to achieve high affinity and selectivity towards Pseudomonas aeruginosa via LecA targeting, while also demonstrating the potential therapeutic application via synergistic photothermal and photodynamic therapy.
Topics & Concepts
Photothermal therapyPseudomonas aeruginosaFluorescenceGlycanTumor ablationNanocompositeBiofilmPhotodynamic therapyLaser ablationNanotechnologyMaterials scienceSelectivityMicrobiologyAblationChemistryLaserCombinatorial chemistryBacteriaBiologyMedicineBiochemistryOrganic chemistryOpticsGlycoproteinGeneticsInternal medicinePhysicsCatalysisBacteriophages and microbial interactionsBiosensors and Analytical DetectionNanoplatforms for cancer theranostics