Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL
Jeffrey Y. K. Wong, Raja Mukherjee, J. Miao, Olena Bilyk, Vivian Triana, Mark Miskolzie, Antoine Henninot, John J. Dwyer, Serhii Kharchenko, Anna D. Iampolska, Dmitriy M. Volochnyuk, Yu‐Shan Lin, Lynne‐Marie Postovit, Ratmir Derda
Abstract
-constrained peptides to expand the previously reported repertoire of phage-displayed bicyclic architectures formed by cross-linking Cys side chains. We anticipate that it will aid the discovery of proteolytically stable bicyclic inhibitors for a variety of protein targets.
Topics & Concepts
MorphogenBicyclic moleculeComputational biologyBiologyGenetically modified organismGeneticsChemistryStereochemistryGeneChemical Synthesis and AnalysisMicrobial Natural Products and BiosynthesisClick Chemistry and Applications