Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J. O’Sullivan, Aline Zoller, Anne F. McGettrick, Alessia Zotta, Emily A. Day, Marı́a Simarro, N. Armstrong, Justin P. Annes, Luke O'neill
Topics & Concepts
Succinate dehydrogenaseChemistryProduction (economics)Interferon γPhysicsStereochemistryBiochemistryInterferon gammaEnzymeEconomicsIn vitroMicroeconomicsinterferon and immune responsesNeutrophil, Myeloperoxidase and Oxidative MechanismsRNA regulation and disease