The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
Gianluca Businello, Paola Parente, Luca Mastracci, Gianmaria Pennelli, Giulia Traverso, Massimo Milione, Elena Bellan, Mauro Michelotto, Andromachi Kotsafti, Federica Grillo, Matteo Fassan
Abstract
Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
Topics & Concepts
Esophageal squamous cell carcinomaPathologyMedicineHead and neckBasal cellHead and neck squamous-cell carcinomaCarcinogenesisCellCancer researchOncologyCarcinomaInternal medicineBiologyHead and neck cancerCancerGeneticsSurgeryCancer-related gene regulationEsophageal Cancer Research and TreatmentRNA modifications and cancer