Palladium-Catalyzed Asymmetric <i>O</i>-1,5-Addition with Oximes via Hydroximation of Unsaturated Esters
Aijun Han, Qitao Tan, Zhi‐Tao He
Abstract
Different from electronically matched 1,4- and 1,6-additions, herein, we disclose an electronically mismatched 1,5-conjugate addition process with oximes as the nucleophiles. By this design, the oxime moieties are readily introduced to the γ-position of the electron-deficient substrates in good yields, excellent regioselectivities, and high enantioselectivities. The corresponding allyl oximes are also conveniently transformed into a series of valuable enantioenriched skeletons.
Topics & Concepts
ChemistryPalladiumConjugateOximeNucleophileCatalysisCombinatorial chemistryOrganic chemistryMathematical analysisMathematicsCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesAsymmetric Hydrogenation and Catalysis