Excessive negative regulation of type I interferon disrupts viral control in individuals with Down syndrome
Louise Malle, Marta Martín-Fernández, Sofija Buta, Ashley Richardson, Douglas Bush, Dusan Bogunovic
Topics & Concepts
BiologyInterferonImmunologyInterferon type IDownregulation and upregulationCD14Down syndromeImmune systemCytokineChromosome 21Viral replicationChromosomeVirusGeneticsGeneDown syndrome and intellectual disability researchSingle-cell and spatial transcriptomicsCell Image Analysis Techniques