Catalyst-dependent chemoselective insertion of diazoalkanes into the N–H/C–H/O–H/C–O bonds of 2-hydroxybenzothiazoles
Lvnan Jin, Xuan Zhou, Yunbo Zhao, Jing Guo, Douglas W. Stephan
Abstract
or TfOH as the catalyst. This affords routes to 54 benzothiazole derivatives. These protocols are scalable and demonstrate the complementary nature of Lewis acid, transition metal and Brønsted acid catalyses.
Topics & Concepts
ChemistryCatalysisBenzothiazoleStereochemistryLewis acids and basesChemoselectivityTransition metalMedicinal chemistryCombinatorial chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions