Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl<sub>4</sub>-induced liver injury in mice
Xiao Meng, Guoyi Tang, Pinhe Liu, Chanjuan Zhao, Qing Liu, Hua‐Bin Li
Abstract
BACKGROUND: ) is often used in animal experiments to study the effects of substances on liver injury and the related mechanisms of action, among which oxidative stress is a major pathogenic factor. AIM: To compare antioxidant and hepatoprotective activities of ten herbs and identify and quantify phytochemicals for the one with strongest hepatoprotection. METHODS: solution in olive oil (8%, v/v, 10 mL/kg). The herb with the strongest hepatoprotective performance was analyzed for the detailed bioactive components by using high-performance liquid chromatography-electrospray ionization source-ion trap tandem mass spectrometry. RESULTS: L. CONCLUSION: This study is of value to assist the selection of more effective natural products for direct consumption and the development of nutraceuticals or therapeutics to manage oxidative stress-related diseases.