PI3K/AKT-mediated autophagy inhibition facilitates mast cell activation to enhance severe inflammatory lung injury in influenza A virus- and secondary Staphylococcus aureus-infected mice
Yuling Tang, Ruijing Su, Qingyue Gu, Yanxin Hu, Hanchun Yang
Topics & Concepts
AutophagyProtein kinase BPI3K/AKT/mTOR pathwayInfluenza A virusStaphylococcus aureusLY294002BiologyImmunologyInflammationMicrobiologyVirusMedicineApoptosisSignal transductionCell biologyBiochemistryGeneticsBacteriaMast cells and histamineImmune Cell Function and InteractionAutophagy in Disease and Therapy