Structural and functional remodeling of the female <i>Apoe</i><sup>−/−</sup> mouse aorta due to chronic cigarette smoke exposure
Yasmeen M. Farra, Jacqueline Matz, Bhama Ramkhelawon, Jessica M. Oakes, Chiara Bellini
Abstract
We studied the effects of chronic cigarette smoking on the structure and function of the aorta in a mouse model of nose-only aerosol inhalation. Our data indicated that exposure to cigarette smoke impairs vascular function by reducing the ability of the aorta to store elastic energy and by decreasing aortic distensibility. Combined with a more vulnerable atherosclerotic phenotype, these findings reveal the biomechanical mechanisms that support the development of cardiovascular disease due to cigarette smoking.
Topics & Concepts
Cigarette smokeAortaMedicineCigarette smokingInternal medicineSmokeCardiologyPhenotypePhysiologyChemistryEnvironmental healthGeneBiochemistryOrganic chemistryCardiovascular Health and Disease PreventionCardiovascular Disease and AdiposityClimate Change and Health Impacts