Protecting-group-free <i>S</i>-glycosylation towards thioglycosides and thioglycopeptides in water
Gao-Lan Zhang, Madhusudhan Reddy Gadi, Xikai Cui, Ding Liu, Jiabin Zhang, Varma Saikam, Christopher Gibbons, Peng George Wang, Lei Li
Abstract
A facile and green <italic>S</italic>-glycosylation method is developed, in which Ca(OH)<sub>2</sub> promoted the coupling of protection-group-free fluoride donors and thiol acceptors in water, affording various thioglycosides and thioglycopeptides.
Topics & Concepts
GlycosylationChemistryProtecting groupGroup (periodic table)FluorideThiolCombinatorial chemistryOrganic chemistryBiochemistryInorganic chemistryAlkylCarbohydrate Chemistry and SynthesisSulfur-Based Synthesis TechniquesAntimicrobial Peptides and Activities