Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response
Lili Ji, Dujuan Wang, Guangzheng Zhuo, Zhe Chen, Liping Wang, Qian Zhang, Yuhang Wan, Guohong Liu, Yunbao Pan
Abstract
This study highlights the pivotal roles of key molecular players in therapeutic response in NPC, providing compelling evidence for their potential application as prognostic biomarkers and therapeutic targets, thereby contributing to precision oncology strategies aimed at improving patient outcomes.
Topics & Concepts
MetabolomicsTranscriptomeReprogrammingNasopharyngeal carcinomaBiologyComputational biologyCancer researchGene expressionCell biologyBioinformaticsMedicineGeneticsCellInternal medicineGeneRadiation therapyCancer, Hypoxia, and MetabolismHead and Neck Cancer StudiesCancer Research and Treatments