Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models
Haley Cirka, Tammy Nguyen
Abstract
Significance: The rise of chronic nonhealing lower extremity wounds among aging, diabetic, obese, and cardiovascular patients has surged. Despite a decade of drug testing in preclinical animal models, few federally approved therapies have emerged. This translational gap raises concerns about the efficacy of current wound healing models and the need for improved research development.
Topics & Concepts
Wound healingAnimal modelAnimal testingMedicineBiologyComputational biologyBioinformaticsData scienceComputer scienceSurgeryEcologyInternal medicineWound Healing and TreatmentsMesenchymal stem cell research3D Printing in Biomedical Research