The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
Giulia Apprato, Giuseppe Ermondi, Giulia Caron
Abstract
A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
Topics & Concepts
Pipeline (software)Computer scienceStrengths and weaknessesQuality (philosophy)MedicineData scienceRisk analysis (engineering)PsychologyProgramming languagePhilosophySocial psychologyEpistemologyProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsPeptidase Inhibition and Analysis