Dual Piperidine-Based Histamine H<sub>3</sub> and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska‐Tłuścik, Bogusław Pilarski, Arkadiusz Leniak, Wojciech Pietruś, Sabina Podlewska, Katarzyna Popiołek-Barczyk, Laura J. Humphrys, M. Carmen Ruiz‐Cantero, David Reiner‐Link, Luisa Leitzbach, Dorota Łażewska, Steffen Pockes, Michał Górka, Adam Zmysłowski, Thierry Calmels, Enrique J. Cobos, Agostino Marrazzo, Holger Stark, Andrzej J. Bojarski, Emanuele Amata, Katarzyna Kieć‐Kononowicz
Abstract
showed a broad spectrum of analgesic activity in both nociceptive and neuropathic pain models based on the novel molecular mechanism.
Topics & Concepts
PiperidineChemistryPiperazineSigma receptorMoietyStereochemistryNeuropathic painNociceptionReceptorPharmacologyBiochemistryOrganic chemistryMedicinePharmacological Receptor Mechanisms and EffectsNeuropeptides and Animal PhysiologyPhenothiazines and Benzothiazines Synthesis and Activities