ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection
Dan Corral, Alison Charton, Maria Z. Krauss, Eve Blanquart, Florence Levillain, Emma Lefrançais, Tamara Sneperger, Zoï Vahlas, Jean‐Philippe Girard, Gérard Eberl, Yannick Poquet, Jean‐Charles Guéry, Rafael J. Argüello, Yasmine Belkaid, Katrin D. Mayer-Barber, Matthew R. Hepworth, Olivier Neyrolles, Denis Hudrisier
Abstract
ILC toward a protective interferon-γ-producing ILC1-like population. This differentiation is controlled by type 1 cytokines and is associated with a glycolytic program. Moreover, a BCG-driven type I milieu enhances the early generation of ILC1-like cells during secondary challenge with Mtb. Collectively, our data reveal how tissue-resident ILCs adapt to type 1 inflammation toward a pathogen-tailored immune response.
Topics & Concepts
Innate lymphoid cellBiologyImmune systemMycobacterium tuberculosisInnate immune systemPhenotypeImmunologyInflammationPopulationAcquired immune systemImmunityTuberculosisFunction (biology)Cell biologyMedicineGeneticsGenePathologyEnvironmental healthIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisImmune Cell Function and Interaction