An All‐in‐One Organic Semiconductor for Targeted Photoxidation Catalysis in Hypoxic Tumor
Wei‐Hua Chen, Zhen Sun, Chunhuan Jiang, Wenbo Sun, Bin Yu, Wei Wang, Lehui Lu
Abstract
Abstract Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT). Although many methods for oxygen generation exist, substantial safety concerns, spatiotenporal uncontrollability, limited efficacy, and complicated procedures have compromised their practical application. Here, we demonstrate a biocompatiable all‐in‐one organic semiconductor to provide a photoxidation catalysis mechanism of action. A facile method is developed to produce gram‐level C 5 N 2 nanoparticles (NPs)‐based organic semiconductor. Under 650 nm laser irradiation, the semiconductor split water to generate O 2 and simultaneously produce singlet oxygen ( 1 O 2 ), showing that the photocatalyst for O 2 evolution and the photosensitizer (PS) for 1 O 2 generation could be synchronously achieved in one organic semiconductor. The inherent nucleus targeting capacity endows it with direct and efficient DNA photocleavage. These findings pave the way for developing organic semiconductor‐based cancer therapeutic agents.