Electrosynthesis of CF<sub>3</sub>‐Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene
Lei Liu, Wangqin Zhang, Chao Xu, Jiaying He, Zhenhui Xu, Zehui Yang, Fei Ling, Weihui Zhong
Abstract
Abstract An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety of polycyclic quinazolinones were successfully synthesized in 52–81% yields under transition metal‐ and oxidant‐free conditions. The Langlois reagent used in this strategy as a CF 3 reagent possesses the advantages of bench‐stablity, cost‐effectivity and high‐efficiency. Additionally, gram‐scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol. magnified image
Topics & Concepts
TrifluoromethylationChemistryAlkeneReagentCombinatorial chemistryCascadeCascade reactionSubstrate (aquarium)Functional groupOrganic chemistryCatalysisTrifluoromethylChromatographyGeologyAlkylPolymerOceanographyFluorine in Organic ChemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization Methods