Ruthenium(<scp>ii</scp>) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells
Ming‐Wei Lin, Shan–Shan Zou, Xinxing Liao, Yu Chen, Di‐Qing Luo, Liang‐Nian Ji, Hui Chao
Abstract
Herein, we developed the first Ru(ii) complex-based bioorthogonal two-photon photosensitizers. Through bioorthogonal labelling, they realize effective tumour-specific photodynamic therapy against triple-negative breast cancer cells.
Topics & Concepts
Bioorthogonal chemistryTriple-negative breast cancerPhotodynamic therapyRutheniumChemistryLabellingCancer researchBreast cancerPhotosensitizerCombinatorial chemistryCancerBiochemistryClick chemistryPhotochemistryMedicineCatalysisInternal medicineOrganic chemistryClick Chemistry and ApplicationsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research Studies