Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
Jeffrey R. Strich, Marcos J. Ramos-Benítez, Davide Randazzo, Sydney Stein, Ashley L. Babyak, Richard T. Davey, Anthony F. Suffredini, Richard Childs, Daniel S. Chertow
Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ExtracellularNeutrophil extracellular trapsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineVirologyConvalescent plasmaImmunologyChemistryPharmacologyInflammationInternal medicineBiochemistryOutbreakInfectious disease (medical specialty)DiseaseNeutrophil, Myeloperoxidase and Oxidative MechanismsCOVID-19 Clinical Research StudiesInflammasome and immune disorders