Splenic Capture and <i>In Vivo</i> Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets
Leon Newman, Dhifaf A. Jasim, Éric Prestat, Neus Lozano, Irene de Lázaro, Yein Nam, Mushref Bakri Assas, Joanne L. Pennock, Sarah J. Haigh, Cyrill Bussy, Kostas Kostarelos
Abstract
intracellular biodegradation of GO sheets with ultrastructural precision. This work offers critical information about biological processing and degradation of thin GO sheets by normal mammalian tissue, indicating that further development and exploitation of GO in biomedicine would be possible.
Topics & Concepts
GrapheneRaman spectroscopyNanotechnologyIn vivoBiodistributionMaterials scienceIntracellularDrug deliveryNanomaterialsSpleenBiophysicsChemistryBiologyBiochemistryImmunologyBiotechnologyOpticsPhysicsGraphene and Nanomaterials ApplicationsCarbon and Quantum Dots ApplicationsGraphene research and applications