Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury
Xianke Zhou, Yadie Xiang, Dier Li, Menghua Zhong, Xue Hong, Yuan Gui, Wenjian Min, Yudan Chen, Xi Zeng, Haili Zhu, Youhua Liu, Shijia Liu, Peng Yang, Fan Fan Hou, Dong Zhou, Haiyan Fu
Abstract
, blockade of ERK abolished limonin's capacity of preventing tubular cell death under hypoxia stress. Our results indicated that limonin is a novel ERK2 activator with strong translational potential in preventing or mitigating AKI.
Topics & Concepts
LimoninMAPK/ERK pathwayPharmacologyAcute kidney injuryAgonistMedicineActivator (genetics)Ex vivoKidneyChemistryCancer researchKinaseReceptorInternal medicineIn vitroBiochemistryAcute Kidney Injury ResearchRenin-Angiotensin System StudiesChronic Kidney Disease and Diabetes