Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus
Aaron B. Benjamin, Madeleine G. Moule, Maruti K. Didwania, Jonathan Hardy, Panatda Saenkham-Huntsinger, Preeti Sule, Josefine Eilsø Nielsen, Jennifer S Lin, Christopher H. Contag, Annelise E. Barron, Jeffrey D. Cirillo
Abstract
Staphylococcus aureus resistance is a consistent problem with a large impact on the health care system. Infections with resistant S. aureus can cause serious adverse effects and can result in death. These antimicrobial peptoids show efficient killing of bacteria both as a biofilm and as free bacteria, often doing so in less than 30 min. As such, these antimicrobials have the potential to alleviate the burden that Staphylococcus infections have on the health care system and cause better outcomes for infected patients.
Topics & Concepts
Staphylococcus aureusCathelicidinAntimicrobialMicrobiologyMedicineAntimicrobial peptidesBiologyBacteriaGeneticsAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationMicrobial Natural Products and Biosynthesis