Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2
Alexander V. Peskin, Flávia Carla Meotti, K.M. Kean, Christoph Göbl, Álbert S. Peixoto, Paul E. Pace, Christopher R. Horne, Sarah G. Heath, Jennifer M. Crowther, Renwick C. J. Dobson, P. Andrew Karplus, Christine C. Winterbourn
Abstract
. This is relevant for Prdx turnover as intermediate mixed disulfides with C172 would also be disruptive and could potentially react with peroxides before resolution is complete.
Topics & Concepts
ChemistrySulfenic acidCysteineReactivity (psychology)PeroxiredoxinThiolSize-exclusion chromatographyActive siteHydrogen peroxideStereochemistryKineticsPeroxidaseCrystallographyEnzymeBiochemistryPathologyAlternative medicineQuantum mechanicsPhysicsMedicineRedox biology and oxidative stressInsect and Pesticide ResearchEnzyme Structure and Function