The GABA <sub>B</sub> receptor mediates neuroprotection by coupling to G <sub>13</sub>
Yunyun Wang, Siyu Gai, Wenhua Zhang, Xuetao Huang, Shumin Ma, Yujia Huo, Yichen Wu, Haijun Tu, Jean‐Philippe Pin, Philippe Rondard, Chanjuan Xu, Jianfeng Liu
Abstract
. Our findings reveal distinct, β-arrestin–independent, context-specific synergistic mechanisms of MAPK activation by G protein–mediated GPCR signaling.
Topics & Concepts
G protein-coupled receptorCell biologyRHOAGABAB receptorNeuroprotectionSignal transductionMAPK/ERK pathwayChemistryBiologyNeuroscienceReceptorBiochemistryAgonistReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology