Combination of Resveratrol and PARP inhibitor Olaparib efficiently deregulates homologous recombination repair pathway in breast cancer cells through inhibition of TIP60-mediated chromatin relaxation
Saptarshi Sinha, Subarno Paul, S. Acharya, Chinmay Das, Somya Ranjan Dash, Subhasmita Bhal, Rajalaxmi Pradhan, Biswajit Das, Chanakya Nath Kundu
Topics & Concepts
PARP1OlaparibChromatinChromatin remodelingMolecular biologyDNA damageBiologyDNA repairHistoneTransfectionAcetylationPARP inhibitorHomologous recombinationChromatin immunoprecipitationPoly ADP ribose polymeraseCell biologyCancer researchChemistryDNACell cultureBiochemistryGeneticsPolymerasePromoterGene expressionGenePARP inhibition in cancer therapyDNA Repair MechanismsCell death mechanisms and regulation