Physical stability enhancement and antimicrobial properties of a sodium ionic cocrystal with theophylline
Siphumelele Majodina, Lubabalo Ndima, Olufunso O. Abosede, Eric C. Hosten, Carolline M. A. Lorentino, Heloísa F. Frota, Leandro S. Sangenito, Marta H. Branquinha, André Luis Souza dos Santos, Adeniyi S. Ogunlaja
Abstract
In the present study, we have described the synthesis and characterisation of the theophylline hydrate (Theo hydrate), cocrystal (Theo–Phen·2H<sub>2</sub>O) and hydrated sodium co-crystal of theophylline (Na–(Theo)<sub>2</sub>ClO·2H<sub>2</sub>O), where Theo = theophylline and Phen = 1,10-phenathroline.
Topics & Concepts
TheophyllineCocrystalHydrateChemistryIonic bondingSodiumInorganic chemistryIonOrganic chemistryHydrogen bondMoleculeEndocrinologyMedicineCrystallography and molecular interactionsCrystal structures of chemical compoundsCrystallization and Solubility Studies