Hybrid molecules of thiadiazole-based benzothioate and benzenesulfonothioate: synthesis, structural analysis, and evaluation as potential inhibitors of thymidine phosphorylase and β-glucuronidase through in vitro and in silico approaches
Yousaf Khan, Shoaib Khan, Wajid Rehman, Rafaqat Hussain, Aneela Maalik, Farhan Ali, Muhammad Usman Ghani Khan, Abdul Sattar, Mohammed A. Assiri
Topics & Concepts
ChemistryThymidine phosphorylaseThymidineIC50EnzymeIn vitroStereochemistryGlycogen phosphorylaseBiochemistryBiochemical and Molecular ResearchSynthesis and biological activityHIV/AIDS drug development and treatment