Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy
Zizhao Tang, Yan Lü, Shixin Zhang, Jing Wang, Qiguang Wang, Yumei Xiao, Xingdong Zhang
Abstract
. Together, this study has successfully developed the proof-of-concept design of "artificial chondrocytes", which could potentially conquer many major barriers of using natural chondrocytes and provided a novel synthetic-cell approach to current therapeutical strategies towards the functional regeneration of articular cartilage.
Topics & Concepts
ChondrogenesisChondrocyteCell biologyMaterials scienceMembraneChemistryNanotechnologyCartilageMedicineAnatomyBiochemistryBiologyMesenchymal stem cellOsteoarthritis Treatment and MechanismsSilk-based biomaterials and applicationsMesenchymal stem cell research