Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1
Lei Zheng, Junlin Cao, Lijie Liu, Hongmei Xu, Lanlan Chen, Liying Kang, Liming Gao
Abstract
We identified LINC00982 as a promising antitumor target for the treatment of patients with gastric cancer. We also determined a regulatory network involved in the pathophysiology of gastric cancer wherein LINC00982 could bind to HEY1 to impair its binding to cathepsin F (CTSF) promoter and hence promote CTSF expression, which aids in better understanding of molecular mechanisms related to gastric tumorigenesis.
Topics & Concepts
Cancer researchCancerTranscription factorCarcinogenesisLong non-coding RNABiologyMedicineOncologyRNAInternal medicineGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases