A Microbe-Derived Efflux Pump Inhibitor of the Resistance-Nodulation-Cell Division Protein Restores Antibiotic Susceptibility in <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>
Rushikesh Tambat, Nisha Mahey, Nishtha Chandal, Dipesh Kumar Verma, Manoj Jangra, Krishan Gopal Thakur, Hemraj Nandanwar
Abstract
in macrophages. Furthermore, the RP1-levofloxacin combination is nontoxic, well-tolerated, and notably effective in a murine lung infection model. In sum, RP1 is a potent EPI and worthy of further consideration as a potentiator to improve the effectiveness of existing antibiotics.
Topics & Concepts
EffluxPseudomonas aeruginosaAntibioticsMicrobiologyEscherichia coliBiologyMultiple drug resistanceAntibiotic resistancePotentiatorIntracellularBacteriaBiochemistryPharmacologyGeneGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyCancer therapeutics and mechanisms