KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
Magdalena Kowalska, Jacek Nowaczyk, Alicja Nowaczyk
Abstract
Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart's work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process.
Topics & Concepts
CardiotoxicityDrugPharmacyPharmacologyMedicineComputer scienceToxicityInternal medicineFamily medicineCardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neuropharmacology Research