Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells
Laura Kuhlmann, Meinusha Govindarajan, Salvador Mejia‐Guerrero, Vladimir Ignatchenko, Lydia Liu, Barbara T. Grünwald, Jennifer Cruickshank, Hal K. Berman, Rama Khokha, Thomas Kislinger
Abstract
-glycoproteome remodeling associated with TNBCs and functional evaluation of an extracted target, which indicate the surface protein PLXNB3 as a potential therapeutic target for TNBCs.
Topics & Concepts
Triple-negative breast cancerCancer researchBiologyGene knockdownProteomicsPlexinCellCell growthGlycoproteomicsBreast cancerCell cultureComputational biologySemaphorinCancerReceptorGeneticsGeneMachine Learning in BioinformaticsUbiquitin and proteasome pathwaysRNA and protein synthesis mechanisms