Water-removable ynamide coupling reagent for racemization-free syntheses of peptides, amides, and esters
Tao Liu, Xue Zhang, Zejun Peng, Junfeng Zhao
Abstract
A water-removable ynamide coupling reagent for racemization-free construction of amide and ester bonds was reported. No column chromatography purification was involved because acidic aqueous work-up removed the byproduct completely.
Topics & Concepts
RacemizationChemistryReagentAmideAqueous solutionOrganic chemistryCoupling (piping)Combinatorial chemistryChromatographyEngineeringMechanical engineeringChemical Synthesis and AnalysisChemical synthesis and alkaloidsAdvanced Synthetic Organic Chemistry