Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents:<i>in silico</i>and<i>in vitro</i>studies
Rana M. El-Masry, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Sara H. Mahmoud, Ahmed Mostafa, Hanan H. Kadry, Sahar M. Abou‐Seri, Azza T. Taher
Abstract
The pharmacophoric features of the novel series of 1,3,4-oxadiazole–oxoindole conjugates (IVa–g) as potential anti-SARS-CoV-2 agents based on the reported M pro inhibitor (Ia) are presented.
Topics & Concepts
ChemistryIn silicoIn vitroConjugateOxadiazoleCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryMathematicsMathematical analysisGeneSynthesis and biological activityComputational Drug Discovery MethodsSynthesis and Biological Evaluation