YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization
Lu Zhao, Ran Li, Jian-Zhong Qiu, Jiangbo Yu, Yang Cao, Rongtao Yuan
Topics & Concepts
BiologyPTENGene knockdownCancer researchRAD51RadioresistanceDNA repairMolecular biologyDownregulation and upregulationYY1Proliferating cell nuclear antigenDNA damageCell cultureCell growthApoptosisGene expressionDNAPromoterGeneBiochemistryPI3K/AKT/mTOR pathwayGeneticsCancer-related molecular mechanisms researchPlant Disease Resistance and GeneticsDNA Repair Mechanisms