Endotoxin and Cytokine Sequential Hemoadsorption in Septic Shock and Multi-Organ Failure
Juan Carlos Ruiz‐Rodríguez, Luis Chiscano‐Camón, Clara Palmada, Adolf Ruiz‐Sanmartín, Marcos Pérez-Carrasco, Nieves Larrosa, Juan José González‐López, M. Hernández, Ricard Ferrer
Abstract
The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins. There are different hemoadsorption systems, we describe in this case report the sequential use of Polymyxin B (PMX) endotoxin-adsorbing column (Toraymixin PMX-20R; Toray, Tokyo, Japan) and Cytosorb® (Cytosorbents Corp., New Jersey, USA).
Topics & Concepts
Septic shockMedicineIntensive care medicinePolymyxin BIntensive carePolymyxinAntibioticsHemofiltrationShock (circulatory)SepsisImmunologySurgeryInternal medicineMicrobiologyHemodialysisBiologySepsis Diagnosis and TreatmentRespiratory Support and MechanismsImmune Response and Inflammation